Eenie, Meenie, Miney, Moe, who is responsible for the antibody-dependent enhancement of Aleutian mink disease parvovirus infection? / 病毒学报
Chinese Journal of Virology
;
(6): 450-455, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-280344
ABSTRACT
Aleutian mink disease parvovirus (AMDV) causes a persistent infection associated with immune complex disease, hypergammaglobulinemia, and high levels of antiviral antibodies. Despite the presence of an antibody, the virus is not cleared in vivo. Pre-existing antibodies may enhance viral infections, by Fc-receptor-mediated antibody-dependent enhancement (ADE), but the mechanism that underlies ADE has not been fully defined. Three models have been proposed, including (1) interactions between antibody and FcR, complement C3 fragment and CR, or between C1q and C1qR, which promotes viral attachment to cells; (2) suppression of IFN-gamma-mediated host-cell antiviral gene expression by the upregulation of negative regulators of pathogen pattern recognition; and (3) the promotion of early IL-10 secretion. In addition, the role of cytokine IL-6 in ADE mediated disease development is discussed, to facilitate a better understanding of the pathogenesis of AMDV infection, as well as give insights into rational vaccine design approaches.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virología
/
Virus de la Enfermedad Aleutiana del Visón
/
Acrecentamiento Dependiente de Anticuerpo
/
Enfermedad Aleutiana del Visón
/
Alergia e Inmunología
/
Genética
/
Visón
/
Anticuerpos Antivirales
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Virology
Año:
2014
Tipo del documento:
Artículo
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