Detection of the complex chromosomal aberrations in acute lymphoblastic leukemia by means of multiplex fluorescence in situ hybridization / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 42-45, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-280737
ABSTRACT
This study was aimed to establish the technique of multiplex fluorescence in situ hybridization (M-FISH) and to explore its usefulness in detection of complex chromosomal aberrations (CCAs) in acute lymphoblastic leukemia (ALL). Five ALL patients with CCAs were analyzed by combining the techniques of conventional cytogenetics (CC) and M-FISH. The results demonstrated that M-FISH confirmed the aberrations previously detected by CC, such as t (9;22), t (1;19) and t (y;1), and revealed new abnormalities as der (1) (137), der (6) t (6;9) (q?;p13), der (1) t (1;11), der (12) t (1;12), der (3) t (3;5), der (2) t (2;16), der (9) (9187) and der (7) (9187), and also corrected the wrong results in CC. Among these abnormalities, der (9) (9187) and der (7) (9187) were reported for the first time. In conclusion, M-FISH has proved to be useful in characterization of the CCAs in ALL, and it is an essential method to refine the karyotype analysis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aberraciones Cromosómicas
/
Hibridación Fluorescente in Situ
/
Análisis Citogenético
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Genética
/
Cariotipificación
/
Métodos
Tipo de estudio:
Estudio diagnóstico
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2006
Tipo del documento:
Artículo
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