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Value influence of different compatibilities of main active parts in yangyintongnao granule on pharmacokinetics parameters in rats with cerebral ischemia reperfusion injury by total amount statistic moment method / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 493-496, 2010.
Artículo en Chino | WPRIM | ID: wpr-280989
ABSTRACT
<p><b>OBJECTIVE</b>To study the influence of the different combinations of the main active parts in Yangyintongnao granule on the pharmacokinetics parameters of the two active components--ligustrazine and puerarin using the method of total amount statistic moment for pharmacokinetics.</p><p><b>METHOD</b>Combinations were formed according to the dosages of the four active parts (alkaloid, flavone, saponin, naphtha) by orthogonal experiment L9 (3(4)). Blood concentrations of ligustrazine and puerarin were determinated by HPLC at different time. Zero rank moment (AUC) and one rank moment (MRT, mean residence time) of ligustrazine and puerarin have been worked out to calculate the total amount statistic moment parameters was analyzed of Yangyintongnao granule by the method of the total amount statistic moment. The influence of different compatibilities on the pharmacokinetics parameters was analyzed by orthogonal test.</p><p><b>RESULT</b>Flavone has the strongest effect than saponin on the total AUC. Ligustrazine has the strongest effect on the total MRT. Saponin has little effect on the two parameters, but naphtha has more effect on both of them. It indicates that naphtha may promote metabolism of ligustrazine and puerarin in rat.</p><p><b>CONCLUSION</b>Total amount statistic moment parameters can be used to guide for compatibilities of TCM.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Medicamentos Herbarios Chinos / Farmacocinética / Daño por Reperfusión / Distribución Aleatoria / Interpretación Estadística de Datos / Ratas Sprague-Dawley / Modelos Animales de Enfermedad / Relación Dosis-Respuesta a Droga / Quimioterapia Tipo de estudio: Ensayo Clínico Controlado / Estudio pronóstico Límite: Animales / Humanos / Masculino Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Medicamentos Herbarios Chinos / Farmacocinética / Daño por Reperfusión / Distribución Aleatoria / Interpretación Estadística de Datos / Ratas Sprague-Dawley / Modelos Animales de Enfermedad / Relación Dosis-Respuesta a Droga / Quimioterapia Tipo de estudio: Ensayo Clínico Controlado / Estudio pronóstico Límite: Animales / Humanos / Masculino Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2010 Tipo del documento: Artículo