Study of components in xingnaojing affecting intestine absorption of gardenia extract / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the influence of ingredients in Xingnaojing,such as moschus, borneol and radix curcumae on intestine absorption kinetics of gardenia extract.</p><p><b>METHOD</b>An in situ intestinal perfusion model of rats was employed to investigate the absorption of geniposide in gardenia extract.</p><p><b>RESULT</b>While gardenia extract was administered solely, the absorptive rate constant (K) of geniposide was (0.055 +/- 0.006) h(-1); But while the extract was co-administered with radix curcumae,moschus and borneol, the K were (0.060 +/- 0.001), (0.066 +/- 0.008), (0.072 +/- 0.010) h(-1), respectively. The K was (0.076 +/- 0.011) h(-1) while the extract in total formulation for Xingnaojing.</p><p><b>CONCLUSION</b>The K, while the extract is co-administered with borneol or total formulation is significantly higher than solely used. Borneol and complex prescription can significantly increase the intestinal absorption of geniposide in gardenia extract.</p>