Linkage analysis of the polymorphism at D17S1878 site with essential hypertension / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the linkage of the polymorphism at D17S1878 site with susceptible gene of essential hypertension.</p><p><b>METHODS</b>Forty-five pedigrees from the high prevalence region of the hypertension were collected. The polymorphism of D17S1878 site was genotyped with genetic analyzer and gene-scan software. Discordant sib pair analysis and affected sib pair analysis were used in linkage analysis.</p><p><b>RESULTS</b>There were significant differences in the age, male, alcohol-consuming, over-salt intake, average systolic pressure, average diastolic pressure, waist-to-hip-ratio, total cholesterol, high-density lipoprotein, and low density lipoprotein between the hypertensive sib and the normotensive sib (P < 0.05). There were eleven alleles at D17S1878 site, and the allele frequency was significantly different between the hypertensive and normotensive sibs (P < 0.05). Forty-three pedigrees were analyzed with affected sib pair analysis (t = 3.05, P < 0.05).</p><p><b>CONCLUSION</b>The polymorphism of D17S1878 may be linked with susceptible genes of essential hypertension.</p>