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Expression of proliferating cell nuclear antigen in severely damaged small intestinal mucosa due to high-dose 5-FU exposure / 南方医科大学学报
Journal of Southern Medical University ; (12): 1860-1862, 2007.
Artículo en Chino | WPRIM | ID: wpr-281521
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of proliferating cell nuclear antigen (PCNA) in severely damaged intestinal mucosa due to high-dose 5-FU exposure.</p><p><b>METHODS</b>Thirty-two adult C57BL/6J mice were subjected to daily intraperitoneal high-dose 5-FU injection at 150 mg/kg for 5 consecutive days, and on days 1, 3, and 5, the mice were sacrificed to obtain the small intestinal tissue for HE straining and immunohistochemistry for detecting PCNA expression. Another 8 mice with intraperitoneal PBS injection served as the control group.</p><p><b>RESULTS</b>High-dose 5-FU exposure of the mice resulted in severe intestinal mucous damage, with complete destruction of the villi and crypts and significantly increased cells positive for PCNA expression (P<0.01).</p><p><b>CONCLUSION</b>High-dose 5-FU treatment can significantly increase the PCNA index, and the cells expressing PCNA can be closely associated with regeneration of the severely damaged mucosa due to the exposure.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Antígeno Nuclear de Célula en Proliferación / Fluorouracilo / Mucosa Intestinal / Intestino Delgado / Metabolismo / Ratones Endogámicos C57BL / Antimetabolitos Antineoplásicos Límite: Animales Idioma: Chino Revista: Journal of Southern Medical University Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Antígeno Nuclear de Célula en Proliferación / Fluorouracilo / Mucosa Intestinal / Intestino Delgado / Metabolismo / Ratones Endogámicos C57BL / Antimetabolitos Antineoplásicos Límite: Animales Idioma: Chino Revista: Journal of Southern Medical University Año: 2007 Tipo del documento: Artículo