Association of galectin-3 and E-cadherin expressions with lymph node metastasis of colon cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1731-1733, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-281550
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation between the expressions of galectin-3 and E-cadherin and lymph node metastasis of colon cancer.</p><p><b>METHODS</b>Immunohistochemistry was employed to examine the expressions of E-cadherin and galectin-3 in 37 colon cancer samples, among which 21 samples underwent RT-PCR for E-cadherin and galectin-3 mRNA expressions. The correlation of E-cadherin and galectin-3 expressions with lymph node metastasis of the tumor was analyzed.</p><p><b>RESULTS</b>The positivity rate of galectin-3 expression was 83.8% (31/37) in these samples. Of the tumor cases with lymph node metastasis, 94.7% (18/19) of the tumors were positive for galectin-3 expression, a rate significantly higher than that in non-metastatic cases. The positivity rate of E-cadherin expression was 59.5% (22/37) in the total cases, and 47.4% (9/19) in the metastatic cases, significantly lower than that in the non-metastatic cases.</p><p><b>CONCLUSION</b>Galectin-3 and E-cadherin expressions are associated with lymph node metastasis of colon cancer and may serve as potential prognostic indicators for colon cancer patients.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Inmunohistoquímica
/
Biomarcadores de Tumor
/
Cadherinas
/
Neoplasias del Colon
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Galectina 3
/
Genética
/
Metástasis Linfática
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Artículo
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