Effect of enalapril on diabetic rat myocardial ultrastructure / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1726-1727, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-281552
ABSTRACT
<p><b>OBJECTIVE</b>To observe the changes in the myocardial ultrastructure of diabetic rats and the effect of enalapril treatment.</p><p><b>METHODS</b>Male Wistar rats were divided into 3 groups, namely the control group, diabetic group and enalapril intervention group. Diabetes was induced with peritoneal injection of streptozotocin in the latter 2 groups, and in enalapril group, the rats were treated with enalapril at the daily oral dose of 2 mg/kg for 1, 3 and 5 months after streptozotocin injection. Histological analysis of the left ventricular tissue was performed with transmission electron microscope 1, 3, and 5 months after establishment of diabetes.</p><p><b>RESULTS</b>Onset of myocardial damages was observed 1 month after the development of diabetes in the rats with gradual time-dependent exacerbation. Enalapril treatment could partially reverse the myocardial destruction in the diabetic rats.</p><p><b>CONCLUSION</b>Enalapril intervention may improve the ultrastructural pathology of the myocardium in diabetic rats, which is suggestive of the action mechanisms of angiotensin-converting enzyme inhibitors in myocardium preservation.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Inhibidores de la Enzima Convertidora de Angiotensina
/
Enalapril
/
Ratas Wistar
/
Estreptozocina
/
Diabetes Mellitus Experimental
/
Quimioterapia
/
Miocardio
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Artículo
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