Effects of 5F from Pteris semipinnate L on growth of human pathological scars in nude mice / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1677-1680, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-281564
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of 5F from Pteris semipinnate L on the growth of human pathological scar in nude mice.</p><p><b>METHODS</b>5F from Pteris semipinnate L was administered at different doses in nude mouse models bearing human pathological scars. The morphology, histology, tumor growth factor-beta1 and type I collagen content of the scar tissues were examined after the administration.</p><p><b>RESULTS</b>Administration of 5F significantly reduced the volume of the implanted pathological scars in the nude mouse models, and histologically, the scar tissue exhibited a transition to the normal scar architecture with decreased TGF-beta1 and type I collagen content.</p><p><b>CONCLUSION</b>5F could effectively inhibit the growth of pathological scars in nude mice.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Medicamentos Herbarios Chinos
/
Extractos Vegetales
/
Química
/
Cicatriz
/
Colágeno Tipo I
/
Pteris
/
Usos Terapéuticos
/
Quimioterapia
/
Factor de Crecimiento Transformador beta1
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Artículo
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