A novel class of anti-inflammatory and analgesic drugs--NO-donating NSAIDs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 352-357, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-281894
ABSTRACT
Traditional non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 selective inhibitors are among the most widely used drugs. However, their significant side effects in gastrointestinal and cardiovascular systems limited the use of these drugs. Recently, research and development of NO-donating NSAIDs (NO-NSAIDs) have become one of the most important strategies to reduce these side effects. NO-NSAIDs may exert a broad range of positive effects in terms of NO-mediated gastrointestinal and cardiovascular safety as well as comparable or increased anti-inflammatory, analgesic properties relative to NSAIDs. This review briefly deals with chemistry of NO-NSAIDs, more details are focused on biological significance, mechanism of action, and therapeutic potential of this novel class of drugs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Cardiotónicos
/
Química
/
Antiinflamatorios no Esteroideos
/
Aspirina
/
Flurbiprofeno
/
Ibuprofeno
/
Naproxeno
/
Inhibidores de la Ciclooxigenasa
/
Donantes de Óxido Nítrico
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2007
Tipo del documento:
Artículo
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