The role of serum hepcidin and ferroportin1 in placenta on iron transfer from mother to fetus / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 307-311, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-282045
ABSTRACT
<p><b>OBJECTIVE</b>To detect the concentration of serum hepcidin and the mRNA expression level of ferroportin1 (FPN1) in the placenta membrane from full term pregnant women with different degree of iron deficiency, and explore their roles for iron transport in placental.</p><p><b>METHODS</b>The concentration of HGB, serum iron (SI) and serum ferritin (SF) of mothers and infants were detected in 55 full term pregnant women and neonates. The expression level of FPN1 mRNA in placental was detected by the RT-PCR technique. The concentration of serum hepcidin was detected by double antibody sandwich biotin avidin enzyme-linked immunosorbent assay. The serum hepcidin level and the FPN1 mRNA expression in the full term placenta from different maternal iron status were compared in three groups.</p><p><b>RESULTS</b>There were no significant differences in the cord blood HGB, SI and SF of newborns from pregnant women with different iron status (P>0.05). The concentration of serum hepcidin of pregnant women among normal, iron deficiency and mild iron deficiency anemia were (193.637±52.219), (176.523±43.875), and (147.623±37.768) μg/L respectively, with statistical significance (F=3.872, P=0.027). The expression levels of FPN1 mRNA among three groups were 0.462±0.077, 0.507±0.074 and 0.551±0.104 respectively, with statistical significance (F=4.767, P=0.013). A negative correlation between maternal serum hepcidin and placental FPN1 mRNA (r=-0.383, P=0.004) was identified.</p><p><b>CONCLUSION</b>There were no significant differences in the iron status of corresponding newborns from pregnant women with different iron status. With the severity of maternal iron deficiency, the concentration of serum hepcidin was down-regulated, while the expression of FPN1 mRNA in placenta was up-regulated.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Placenta
/
ARN Mensajero
/
Ensayo de Inmunoadsorción Enzimática
/
Anemia Ferropénica
/
Proteínas de Transporte de Catión
/
Sangre Fetal
/
Hepcidinas
/
Hierro
/
Madres
Límite:
Femenino
/
Humanos
/
Recién Nacido
/
Embarazo
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2015
Tipo del documento:
Artículo
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