P2Y6 receptor and immunoinflammation / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 161-164, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-282068
ABSTRACT
The immunocytes microglia in the central nervous system (CNS) were reported to play a crucial role in neurodegeneration. As a member of P2 receptors family, purinoceptor P2Y6 has attracted much attention recently. Previous studies showed that purinoceptor P2Y6 mainly contributed to microglia activation and their later phagocytosis in CNS, while in immune system, it participated in the secretion of interleukin (IL)-8 from monocytes and macrocytes. So there raises a question whether purinoceptor P2Y6 also takes part in neuroinflammation? Thus, this review mainly concerns about the properties and roles of purinoceptor P2Y6, including (1) structure of purinoceptor P2Y6; (2) distribution and properties of purinoceptor P2Y6; (3) relationships between purinoceptor P2Y6 and microglia; (4) relationships between purinoceptor P2Y6 and immunoinflammation. Itos proposed that purinoceptor P2Y6 may play a role in neuroinflammation in CNS, although further research is still required.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fagocitosis
/
Fisiología
/
Monocitos
/
Química
/
Receptores Purinérgicos P2
/
Microglía
/
Alergia e Inmunología
/
Genética
/
Inflamación
/
Metabolismo
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2009
Tipo del documento:
Artículo
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