A pilot study on the combined therapy of granulocyte-macrophage colony-stimulating factor and hepatitis B vaccine on chronic hepatitis B virus carrier children / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1824-1828, 2002.
Artículo
en Inglés
| WPRIM
| ID: wpr-282082
ABSTRACT
<p><b>OBJECTIVE</b>To observe the efficacy of treating intrauterine infected chronic hepatitis B virus (HBV) carrier children with a combination of granulocyte-macrophage colony-stimulating factor (GM-CSF) or hepatitis B immunoglobulin (HBIG) plus recombinant hepatitis B vaccine (rHBvac).</p><p><b>METHODS</b>A total of 27 chronic HBV infected children, who were born to HBV carrier mothers and received hepatitis B immunoprophylaxis at birth, were randomized into 2 groups one receiving a combined therapy of 50 micro g of GM-CSF plus 10 micro g of rHBvac injected intramuscularly at the same location (GM-CSF group, 14 children) or 200 IU HBIG and 10 micro g rHBvac in different muscles (HBIG group, 13 children) on a monthly four-dose schedule. HBV-DNA quantification and other HBV serological markers were tested before and after the four-dose therapy.</p><p><b>RESULTS</b>Twelve children in each group completed the study. Of them, 3 children in the GM-CSF group and 4 in the HBIG group had elevated serum alanine transaminase (ALT) before the trial, and then 2 in each group became ALT normal after the treatment. Before the therapy, hepatitis B e antigen (HBeAg) positivity was found in nine children in the GM-CSF group and 10 in the HBIG group. One from each group had an HBeAg/anti-HBe seroconversion after the treatment. The quantity of HBV-DNA was significantly lower after the treatment (P = 0.023) in GM-CSF group, but was not significantly reduced in HBIG group. No subjects were found to be negative for hepatitis B surface antigen (HBsAg) after the treatment, and no serious adverse events occurred in either group.</p><p><b>CONCLUSION</b>Combined GM-CSF and rHBvac therapy inhibit HBV replication in carrier children who were not protected after treatment with immunoprophylaxis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
Sangre
/
ADN Viral
/
Inmunoglobulinas
/
Vacunas Sintéticas
/
Portador Sano
/
Proyectos Piloto
/
Factor Estimulante de Colonias de Granulocitos y Macrófagos
/
Vacunas contra Hepatitis B
/
Terapia Combinada
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Niño
/
Child, preschool
/
Humanos
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2002
Tipo del documento:
Artículo
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