Determination of danshensu in rat serum after oral administer compound Salvia recipe / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 562-565, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-282266
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the absorption of the water soluble components of Salvia miltiorrhiza and establish methods to determine Danshensu in rat serum after ig compound Salvia recipe.</p><p><b>METHOD</b>Used liquid-liquid extraction to deal with the serum, then determined the sample by high-performance liquid chromatography. The conditions for HPLC were as the following the mobile phase, CH3OH-CH3CN-0.5% CH3COOH (2.53.594) with a flow rate of 1.0 mL.min-1; detection wavelength, 281 nm; internal standard, 4-hydroxy-benzoic acid.</p><p><b>RESULT</b>Danshensu and an unknown compound whose reserved time was little shorter than protocatechuic aldehyde were found in the rat serum after ig compound Salvia recipe, while protocatechuic aldehyde weren't found in the serum.</p><p><b>CONCLUSION</b>Danshensu can be absorbed into blood after ig compound Salvia recipe.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plantas Medicinales
/
Sangre
/
Medicamentos Herbarios Chinos
/
Farmacocinética
/
Química
/
Ratas Sprague-Dawley
/
Salvia miltiorrhiza
/
Combinación de Medicamentos
/
Panax
/
Lactatos
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2003
Tipo del documento:
Artículo
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