Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 13-17, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-282316
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between CYP1A1, GSTM1, T1, UGT1A7 polymorphisms and colorectal cancer risk.</p><p><b>METHODS</b>A case-control study of 140 patients with cancers and 343 health controls was conducted to investigate the role of CYP1A1, GSTM1, T1, UGT1A7 polymorphisms in colorectal cancer. Gene-gene interactions among CYP1A1, GSTM1, T1, UGT1A7 polymorphisms were detected by case-control study and case-only study. Genotypes of four genes polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and unconditional logistic regression was adopted to analyze the data.</p><p><b>RESULTS</b>The CC, TC and CC genotypes of CYP1A1 T6235C significantly decreased the colorectal cancer risk as compared to TT genotype (OR = 0.493, 95% CI 0.254-0.956, OR = 0.638, 95% CI 0.427-0.952). GSTM1 and GSTT1 null genotype had no significant association with the increased risk of colorectal cancer while the mutant variants of UGT1A7 might increase the risk of colorectal cancer significantly (OR = 2.501, 95% CI 1.456-4.296). The CORvalue for the gene-gene interactions between CYP1A1 variant and the null genotype of GSTT1, GSTM1-deleted and GSTT1-deleted genotype in the case-only design were 2.617 (95% CI 1.015-6.752) and 3.935 (95% CI 1.323-11.706), respectively. There was no significant interaction between CYP1A1 and GSTM1, CYP1A1 and UGT1A7.</p><p><b>CONCLUSION</b>This study suggests that CYP1A1 and UGT1A7 variants might be associated with colorectal cancer. CYP1A1 and GSTM1 might interact on GSTT1 to influence the risk of colorectal cancer.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo de Longitud del Fragmento de Restricción
/
Neoplasias Colorrectales
/
Modelos Logísticos
/
Reacción en Cadena de la Polimerasa
/
Estudios de Cohortes
/
Estudios de Seguimiento
/
Citocromo P-450 CYP1A1
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Frecuencia de los Genes
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Preventive Medicine
Año:
2006
Tipo del documento:
Artículo
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