Twin study on serum leptin and soluble leptin receptor in pubertal girls / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 245-248, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-282354
ABSTRACT
<p><b>OBJECTIVE</b>To explore the changes of serum leptin, soluble leptin receptor (SOB-R) concentrations and free leptin index (FLI) throughout the puberty in females, and estimate the effects of genetic and environmental factors on these indices.</p><p><b>METHODS</b>The population studied consists of 180 pairs of twins in 6 to 18 years old 132 pairs of monozygotic twins and 48 pairs of dizygotic twins, who were all from Qingdao city, Shandong Province. Anthropometric and sexual characteristics were examined, fasting serum leptin and SOB-R contents were assayed by immunoradiometric assay and ELISA respectively.</p><p><b>RESULTS</b>Serum leptin concentrations increased and SOB-R decreased throughout puberty (P < 0.05), brought out a sustained increase of FLI, especially in 7-9 and 12-14 years old (from 10.1 to 32.3 and 41.8 to 82.1 respectively); Leptin and FLI were positively, and SOB-R negatively correlated with morphological indices (correlation coefficients from 0.54 to 0.76, -0.23 to -0.42, respectively). Heritability of girl's serum leptin, SOB-R and FLI were 0.37, 0.84, 0.46 respectively.</p><p><b>CONCLUSIONS</b>Serum free leptin index surge at 7-9 and 12-14 years old might be a predictor or trigger of the puberty onset and menarche, respectively; FLI might be determined by both genetic and environmental factors. Leptin should be substantially influenced by environment and reflect the fat mass of body compositions. SOB-R should be predominantly controlled by genetic factors yet. Genetic influence might be important in pubertal development and metabolic disorders.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Gemelos Dicigóticos
/
Gemelos Monocigóticos
/
Sangre
/
Ensayo de Inmunoadsorción Enzimática
/
Ensayo Inmunorradiométrico
/
Pubertad
/
Leptina
/
Receptores de Leptina
Tipo de estudio:
Estudio pronóstico
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Preventive Medicine
Año:
2005
Tipo del documento:
Artículo
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