Characterization of the changes in comparative genomic hybridization in esophageal cancer patients with family history / 南方医科大学学报
Journal of Southern Medical University
; (12): 1166-1169, 2009.
Article
en Zh
| WPRIM
| ID: wpr-282592
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To characterize the profile of chromosomal imbalances in esophageal cancer (EC) with or without family history in Linzhou, Henan Province of China.</p><p><b>METHODS</b>Comparative genomic hybridization (CGH) was used to examine 13 cases with positive family history of EC and 32 cases with negative family history of EC. RESULTS DNA copy number gains on chromosome 10q was observed only in the cases with postivie family history of EC (30%), and none in cases with a negative family history (P<0.05). DNA copy number losses on chromosome 15q were significantly higher in cases with postivie family history (38% vs 6%, P<0.05). The frequency of DNA copy number gains in 3q, 5p, 7p, 8q and DNA copy number losses in 3p, 19q, 9q were similar in the two groups (both beyond 20%) (P>0.05).</p><p><b>CONCLUSIONS</b>Frequent DNA copy number gains on chromosome 10q and losses on chromosome 15q in EC casers with postivie family history indicate that these chromosome sites may harbor the genes related to high susceptibility to EC. Such chromosomal sites as 3q, 5p, 7p, 8q, 3p, 19q, and 9q may contain important genes related with the environmental risk factors of esophageal carcinogenesis.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Cromosomas Humanos Par 10
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Cromosomas Humanos Par 15
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Neoplasias Esofágicas
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China
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Salud de la Familia
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Eliminación de Gen
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Predisposición Genética a la Enfermedad
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Trastornos de los Cromosomas
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Hibridación Genómica Comparativa
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Genética
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Article