Role of AT2 receptors on angiotensin II-induced tumor necrosis factor alpha and interleukin 1 beta secretion in adult rat cardiac fibroblasts / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1307-1309, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-283144
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of AT2 receptors in the secretion of tumor necrosis factor alpha (alpha-TNF) and interleukin 1 beta (IL1 beta) in adult rat cardiac fibroblasts.</p><p><b>METHODS</b>Adult rat cardiac fibroblasts in in vitro culture were divided into control, Ang II, AngII + Losartan, and AngII + PD123319 groups with corresponding treatments. Radioimmunoassay was used to determine alpha-TNF and IL1 beta levels in the supernatant of the treated cardiac fibroblasts.</p><p><b>RESULTS</b>Ang II treatment resulted in significantly increased alpha-TNF and IL1 beta levels. Compared with AngII group, IL1 beta level was decreased by 69.1% and 78.7% and alpha-TNF by 58.7% and 65.9% after blocking AT1 and AT2 receptors, respectively.</p><p><b>CONCLUSION</b>AT2 receptors are involved in alpha-TNF and IL1 beta secretions in cardiac fibroblasts.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Angiotensina II
/
Regulación de la Expresión Génica
/
Factor de Necrosis Tumoral alfa
/
Ratas Sprague-Dawley
/
Secreciones Corporales
/
Biología Celular
/
Receptor de Angiotensina Tipo 2
/
Interleucina-1beta
/
Fibroblastos
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Artículo
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