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Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2255-2258, 2011.
Artículo en Chino | WPRIM | ID: wpr-283215
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the contribution of mitochondrial pathway in the apoptosis induced by puerarin (PUE) in pulmonary artery smooth muscle cells.</p><p><b>METHOD</b>Cultured rat pulmonary artery smooth muscle cells (PASMC) were intervened by high, middle and low dose of puerarin (1.5 x 10(-3), 1.5 x 10(-4), 1.5 x 10(-5) mol x L(-1)). The change of mitochondrial membrane potential was observed. Western blot detected the expression of apoptosis-related gene Caspase-9, Bax and Bcl-2 protein.</p><p><b>RESULT</b>Compared with the control group, mitochondrial membrane potential significantly decreased in puerarin groups. Puerarin can enhance the expression of Caspase-9 and Bax protein, decrease the expression of Bcl-2 protein. Puerarin also has a concentration-dependent on the induction of PASMC.</p><p><b>CONCLUSION</b>Puerarin can induce PASMC apoptosis through mitochondrial pathway.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / Arteria Pulmonar / Células Cultivadas / Ratas Wistar / Apoptosis / Proteínas Proto-Oncogénicas c-bcl-2 / Biología Celular / Miocitos del Músculo Liso / Caspasa 9 Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / Arteria Pulmonar / Células Cultivadas / Ratas Wistar / Apoptosis / Proteínas Proto-Oncogénicas c-bcl-2 / Biología Celular / Miocitos del Músculo Liso / Caspasa 9 Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2011 Tipo del documento: Artículo