Preparation and quality evaluation of quercetin self-emulsifyied drug delivery systems / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To prepare the quercetin self-emulsified formulation and evaluate its quality.</p><p><b>METHOD</b>The quercetin self-emulsified formulation was optimized based on the quercetin solubility in different oils, and the self-microemulsified efficiency of various combinations of emulsifier and co-emulsifier evaluated using the pseudo-ternary phase diagram. The microemulsion of morphology, size and zeta potential were examined. The quercetin of solubility in self-emulsified system was tested and the formulation stability was investigated by accelerated experiment.</p><p><b>RESULT</b>The blank self-emulsified system was composed of ethyl oleate/Cremophor EUL/butanol with weight ratio of 10 54 36. After being dilutied with water, the morphology of microemulsion was homogeneous small spherical drops observed under the electro-microscopy. The particle size and the zeta potential were 16.3 +/- 4.6 nm and 2.1 +/- 0.8 mV, respectively. The solubility of quercetin in self-emulsifing system was (62.42 +/- 0.11) mg x mL(-1), increased 2 229 folds compared with that of in water. The quality of quercetin self-emulsified formulation was stable during the 3 months storage at 40 degrees C.</p><p><b>CONCLUSION</b>The solubility of quercetin is significantly increased in self-emulsified system and the formulation is stable and easy to prepare.</p>