Effect of combination glycyrrhiizin and triptolide on TNF-alpha and IL-10 in serum of collagen induced arthritis rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 414-417, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-283466
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of combination therapy with glycyrrhizin (GL) and triptolide (TP) on collagen-induced arthritis (CIA) rats.</p><p><b>METHOD</b>Sixty male SD rats were randomly divided into 6 groups the model group, the TP group, the GL group, and combination 1, 2, 3 groups. The models were induced by collagen type II. The arthritis index (AI) and the edema rate were detected as curative effect, and the level of antibodies to collagen, TNF-alpha and IL-10 were measured by ELISA.</p><p><b>RESULT</b>The combination therapy with GL and TP significantly reduced the paw edema and arthritis index of CIA rats (P <0. 01 ), and the combination therapy can increase the level of IL-10, while decrease the level of TNF-alpha, and the level of antibodies to collagen decreased too (P <0.05, P <0.01).</p><p><b>CONCLUSION</b>Combine 26.78 mg x kg(-1) GL with 13.40 microg x kg(-1) TP can significantly inhibited the CIA, and the effect equal to the dosage of 17. 86 microg x kg(-1) TP. It supports the possible of GL in combination with TP to reduce the dose and side effects related to TP.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Fenantrenos
/
Plantas Medicinales
/
Artritis Experimental
/
Sangre
/
Inmunoglobulina G
/
Distribución Aleatoria
/
Química
/
Antiinflamatorios no Esteroideos
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2007
Tipo del documento:
Artículo
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