The experimental study on telomerase activity and expression of p53 and c-myc genes in tongue cancer / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 274-276, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-283604
ABSTRACT
<p><b>OBJECTIVE</b>To study telomerase activity and expression of oncogenes c-myc and p53 in tongue cancer, analyse the interaction among them, and assess their possible correlations with tongue cancer clinicopathological features.</p><p><b>METHODS</b>To detective the telomerase activity by TRAP and examine the positive expression of c-myc and p53 in tongue cancer by hybridization in situ.</p><p><b>RESULTS</b>A high telomerase activity existed in lower differentiated tongue cancer (P < 0.05); the positive expression of c-myc increased significantly in lower grade tongue cancer (P < 0.05) and the positive expression of p53 decreased increasingly in tongue cancer accompanied with lymph node metastasis (P < 0.05).</p><p><b>CONCLUSION</b>Telomerase may play a key role in the tumorigenesis of tongue cancer. Meantime, c-myc and p53 exerts important effect on telomerase activation during the course of tongue cancer generation and development.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias de la Lengua
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Proteína p53 Supresora de Tumor
/
Proteínas Proto-Oncogénicas c-myc
/
Telomerasa
/
Genética
/
Metástasis Linfática
/
Metabolismo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2003
Tipo del documento:
Artículo
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