Epigenetics of hepatocellular carcinoma: a new horizon / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2349-2360, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-283760
ABSTRACT
Epigenetic changes refer to stable alterations in gene expression with no underlying modifications in the genetic sequence itself. It has become clear that not only gene variations but also epigenetic modifications may contribute to varied diseases, including cancer. This review will provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and miRNA regulation, contribute to hepatocellular carcinoma (HCC) dissemination, invasion, and metastasis. Additionally, the reversal of dysregulated epigenetic changes has emerged as a potential strategy for the treatment of HCC, and we will summarize the latest epigenetic therapies for HCC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Carcinoma Hepatocelular
/
Metilación de ADN
/
MicroARNs
/
Epigénesis Genética
/
Genética
/
Neoplasias Hepáticas
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2012
Tipo del documento:
Artículo
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