Effects of Yuquan pills on pharmacokinetics of metformin hydrochloride in diabetic rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2133-2139, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-283778
ABSTRACT
<p><b>OBJECTIVE</b>To study effects of Yuquan pills on the pharmacokinetics process of metformin hydrochloride in diabetic rats.</p><p><b>METHOD</b>After administration Yuquan pills 7 day to the diabetic rats, the metformin hydrochloride was orally administrated, then the blood samples were collected at different time. The concentrations of metformin hydrochloride in plasma were determined by HPLC method and the pharmacokinetic parameters were calculated.</p><p><b>RESULT</b>The pharmacokinetic parameter Cmax of the controlling group and the testing group were respectively, 18.95, 21.76 mg x L(-1); t1/2 were 1,069.8, 1,767.4 min, respectively; CL/F were 0.013, 0.008 L x min(-1) x kg(-1); AUC were 10,042.1, 10,712.2 mg z L(-1) x min(-1) respectively.</p><p><b>CONCLUSION</b>The pharmacokinetics process of metformin hydrochloride in diabetic rats fits one-compartment model. Yuquan pills has a significant effect on the pharmacokinetics of metformin hydrochloride in diabetic rats.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Medicamentos Herbarios Chinos
/
Farmacocinética
/
Cromatografía Líquida de Alta Presión
/
Ratas Wistar
/
Usos Terapéuticos
/
Diabetes Mellitus Experimental
/
Interacciones Farmacológicas
/
Quimioterapia
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2008
Tipo del documento:
Artículo
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