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Nilotinib treatment for imatinib resistant or intolerant chronic myelogenous leukemia / 中华血液学杂志
Chinese Journal of Hematology ; (12): 11-15, 2010.
Artículo en Chino | WPRIM | ID: wpr-283895
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the safety and efficacy of nilotinib in chronic myelogenous leukemia (CML) patients with resistance or intolerance to imatinib.</p><p><b>METHODS</b>Thirty-five CML patients after imatinib failure or intolerance received oral administration of 400 mg nilotinib twice daily. The overall survival, hematologic and cytogenetic responses, as well as adverse events were evaluated.</p><p><b>RESULTS</b>The median duration of nilotinib therapy was 11 (1 - 23) months, with a median follow-up of 19 months. Nonhematologic adverse events were mostly of grade 1-2. The most common ones possibly related to nilotinib were increase of bilirubin (76%) and rash (46%). Grade 3-4 hematologic adverse events includes thrombocytopenia (37%), neutropenia (26%) and anemia (26%). Nilotinib was proved to be well-tolerated in this study. Grade 3-4 hematologic adverse events happened more frequently in advanced phase CML. The rate of major cytogenetic response in chronic phase (CP) CML was much higher than those in advanced CML (38.5% vs 22.2%). The median time to major cytogenetic response was 3 months. The estimated overall survival at 18 months was (93.5 +/- 1.0)%.</p><p><b>CONCLUSION</b>Nilotinib is a more effective and safe treatment option for imatinib-resistant or -intolerant CML-CP patients.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Piperazinas / Benzamidas / Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Resultado del Tratamiento / Resistencia a Antineoplásicos / Usos Terapéuticos / Quimioterapia / Mesilato de Imatinib Límite: Humanos Idioma: Chino Revista: Chinese Journal of Hematology Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Piperazinas / Benzamidas / Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Resultado del Tratamiento / Resistencia a Antineoplásicos / Usos Terapéuticos / Quimioterapia / Mesilato de Imatinib Límite: Humanos Idioma: Chino Revista: Chinese Journal of Hematology Año: 2010 Tipo del documento: Artículo