The impact of platelet membrane autoantibodies on high-dose dexamethasone therapy in patients with idiopathic thrombocytopenic purpura / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 619-621, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-283936
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the impact of platelet membrane glycoprotein (GP)-specific autoantibodies on high-dose dexamethasone therapy in patients with idiopathic thrombocytopenic purpura (ITP).</p><p><b>METHODS</b>Modified direct monoclonal antibody immobilization of platelet antigen assay (MAIPA) was used to detect platelet GPIIb/IIIa and/or GPI b specific autoantibodies. All patients received oral dexamethasone 40 mg/d for 4 days.</p><p><b>RESULTS</b>The response rate of high-dose dexamethasone in GPIIb/IIIa and/or GPIb specific autoantibody-negative patients was significantly different from that of antibody-positive patients (P<0.05). The response rate of GPIIb/IIIa specific autoantibody-positive patients was lower than that of antibody-negative patients (P<0.05). GPIb specific autoantibody had no significant impact on the efficacy of high-dose dexamethasone (P>0.05).</p><p><b>CONCLUSION</b>Platelet membrane GPIIb/IIIa-specific autoantibody can be a potential negative indicator for ITP patients'response to high-dose oral dexamethasone.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Autoanticuerpos
/
Sangre
/
Dexametasona
/
Resultado del Tratamiento
/
Púrpura Trombocitopénica Idiopática
/
Complejo GPIIb-IIIa de Glicoproteína Plaquetaria
/
Complejo GPIb-IX de Glicoproteína Plaquetaria
/
Usos Terapéuticos
/
Quimioterapia
/
Alergia e Inmunología
Límite:
Adolescente
/
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2009
Tipo del documento:
Artículo
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