Influence of S-nitrosoglutathione on the membrane glycoprotein of frozen platelets / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1046-1053, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-283984
ABSTRACT
This study was purposed to explore the influence of S-nitrosoglutathione (GSNO) on membrane glycoprotein of frozen platelet. The levels of membrane glycoprotein on fresh liquid platelets, frozen platelets and frozen platelets with GSNO were measured by flow cytometry. The results showed that the GSNO obviously decreased platelet aggregation, the PAC-1 change in the three groups was not significant. The changes of CD42b and CD62P in fresh liquid platelet group, frozen platelet group and frozen platelets with GSNO were significant different. The change of membrane glycoprotein in above-mentioned three group was not significant. It is concluded that the GSNO inhibits platelet aggregation, maintains the function of platelets and may be used as a cryoprotectant. When frozen platelets were added with GSNO, the molecular rearrangement, structure change and other mechanism may occur in platelets.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Plaquetas
/
Conservación de la Sangre
/
Glicoproteínas de Membrana Plaquetaria
/
Activación Plaquetaria
/
Complejo GPIb-IX de Glicoproteína Plaquetaria
/
Selectina-P
/
S-Nitrosoglutatión
/
Congelación
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2013
Tipo del documento:
Artículo
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