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C-kit mutation in acute myeloid leukemia patients with AML1-ETO fusion gene and its clinical significance / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 839-842, 2013.
Artículo en Chino | WPRIM | ID: wpr-284024
ABSTRACT
This study was aimed to investigate the c-kit mutation in acute myeloid leukemia (AML) patients with AML1-ETO and analyze its relation with clinical and laboratorial features and prognosis. PCR and sequencing methods were used to detect the c-kit 17 exon mutations in 31 AML patients with AML1-ETO. The relation of the c-kit mutation with clinical features, results of laboratorial examination and prognosis of disease were analyzed. The results showed that the c-kit mutation was found in 14 out of 31 AML patients and the mutation frequency was 45.16%. Male patients had a higher incidence of c-kit mutation than that of female patients (P = 0.020). The proportion of patients with newly diagnosed white blood cell>10×10(9)/L and with extramedullary infiltration in mutated group were higher than those in unmutated group respectively. No significant difference was observed at the age (P = 0.437) and the rate of bone marrow blasts(P = 0.510) between the above mentioned two groups. The difference in complete remission rate (64.29% vs 80%, P = 0.344)and relapse rate (58.33% vs 21.43%, P = 0.054) between c-kit mutated and c-kit unmutated groups were not significant. While the c-kit mutated group had a significant higher death rate as compared with c-kit unmutated group (57.14% vs 20%, P = 0.039). It is concluded that the c-kit mutation is frequent in AML patients with AML1-ETO and the c-kit mutated patients have a poor prognosis. It is important to detect c-kit mutation in routine clinical practice for patient's risk stratification, evaluation of prognosis and selection of effective treatment.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Pronóstico / Análisis Mutacional de ADN / Leucemia Mieloide Aguda / Proteínas de Fusión Oncogénica / Resultado del Tratamiento / Proteínas Proto-Oncogénicas c-kit / Subunidad alfa 2 del Factor de Unión al Sitio Principal / Proteína 1 Compañera de Translocación de RUNX1 / Genética Tipo de estudio: Estudio pronóstico Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Pronóstico / Análisis Mutacional de ADN / Leucemia Mieloide Aguda / Proteínas de Fusión Oncogénica / Resultado del Tratamiento / Proteínas Proto-Oncogénicas c-kit / Subunidad alfa 2 del Factor de Unión al Sitio Principal / Proteína 1 Compañera de Translocación de RUNX1 / Genética Tipo de estudio: Estudio pronóstico Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2013 Tipo del documento: Artículo