Progress of study on PML in cancer stem cell of hematologic malignancies / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 796-800, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-284032
ABSTRACT
The promyelocytic leukemia protein (PML), encoded by PML gene, plays a tumor suppressor in acute promyelocytic leukemia and other hematologic malignancies. Recent evidence indicates that PML involves in regulating multiple cell biological function, regulates self-renewal and maintains stable function in stem cell/cancer stem cell of multiple tissues, leading to drug resistance of cancer. This review summarizes the latest research advances about the relationship and therapeutic options between PML and cancer stem cell of hematologic neoplasms, aiming to propose a new avenue for blood cancer treatment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factores de Transcripción
/
Células Madre Neoplásicas
/
Sangre
/
Proteínas Nucleares
/
Neoplasias Hematológicas
/
Proteínas Supresoras de Tumor
/
Proteína de la Leucemia Promielocítica
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2013
Tipo del documento:
Artículo
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