Microdeletions in the Y chromosome of patients with idiopathic azoospermia / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 111-115, 2002.
Artículo
en Inglés
| WPRIM
| ID: wpr-284062
ABSTRACT
<p><b>AIM</b>To evaluate the occurrence and prevalence of microdeletions in the gamma chromosome of patients with azoospermia.</p><p><b>METHODS</b>DNA from 29 men with idiopathic azoospermia was screened by polymerase chain reaction (PCR) analysis with a set of gamma chromosome specific sequence-tagged sites (STSs) to determine microdeletions in the gamma chromosome.</p><p><b>RESULTS</b>Deletions in the DAZ (deleted in azoospermia) loci sgamma254 and sgamma255 were found in three patients with idiopathic azoospermia, resulting in an estimated frequency of deletions of 10.7% in idiopathic azoospermia men.</p><p><b>CONCLUSION</b>We conclude that PCR analysis is useful for the diagnosis of microdeletions in the Y chromosome, which is important when deciding the suitability of a patient for assisted reproductive technology such as testicular sperm extracion-intracytoplasmic sperm injection (TESE-ICSI).</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oligospermia
/
Prolactina
/
Testosterona
/
Sangre
/
Hormona Luteinizante
/
Secuencia de Bases
/
Heterocromatina
/
Reacción en Cadena de la Polimerasa
/
Lugares Marcados de Secuencia
/
Eliminación de Secuencia
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Asian Journal of Andrology
Año:
2002
Tipo del documento:
Artículo
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