Expression and clinical significance of circadian gene Per2 in non-small cell lung cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 129-131, 2013.
Article
en Zh
| WPRIM
| ID: wpr-284224
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of Per2 in non-small cell lung cancer (NSCLC), and analyze its clinical significance.</p><p><b>METHODS</b>The expression of Per2 was determined in 60 NSCLC and 20 normal lung tissues by immunohistochemical assay, and the relationship between Per2 expression and clinicopathological features was analyzed.</p><p><b>RESULTS</b>The positive expression rates of Per2 in NSCLC and normal lung tissues were 71.7% and 95.0%, respectively (P < 0.05). The expression of Per2 in NSCLC was correlated with pathological differentiation and TNM stage (P < 0.05).</p><p><b>CONCLUSION</b>The expression of Per2 in NSCLC is decreased. The negative expression of Per2 may contribute to the development and invasion in NSCLC.</p>
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Índice:
WPRIM
Asunto principal:
Patología
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Cirugía General
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Fumar
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Regulación Neoplásica de la Expresión Génica
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Carcinoma de Pulmón de Células no Pequeñas
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Proteínas Circadianas Period
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Clasificación del Tumor
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Neoplasias Pulmonares
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Metástasis Linfática
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Metabolismo
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Año:
2013
Tipo del documento:
Article