Isolated limb hyperthermic perfusion chemotherapy for melanoma of the extremities / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 937-939, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-284254
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of isolated limb hyperthermic perfusion chemotherapy for melanoma of the extremities.</p><p><b>METHODS</b>Limb isolated hyperthermic perfusion chemotherapy was performed in 41 patients with malignant melanoma of the extremities, and then the primary lesions in 24 patients were removed at 14 - 21 days after chemotherapy. Tumor necrosis was examined by pathology.</p><p><b>RESULTS</b>Among the 41 patients, 40 cases were followed up for 6-113 months, and one was lost. There was no local recurrence in those patients. 29 cases were followed up for more than 3 years, and 26 of them were surviving. Forteen cases were followed up for more than five years, among them 9 cases were surviving. The 3-year and 5-year survival rates of the whole group were 95.0% and 70.0%, respectively. The average reduction of the tumor volume was 55.6% after perfusion. The pathological examination showed that tumor necrosis was 90% - 100% (complete response) in 21 cases (87.5%) and 60% - 89% (partial response) in 3 cases (12.5%).</p><p><b>CONCLUSIONS</b>The isolated limb hyperthermic perfusion chemotherapy is an effective treatment of limb malignant melanoma. It can significantly reduce the local recurrence rate, and improve the 5-year survival rate, prognosis and the quality of life of the patients.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Calidad de Vida
/
Neoplasias de los Tejidos Blandos
/
Inducción de Remisión
/
Quimioterapia del Cáncer por Perfusión Regional
/
Tasa de Supervivencia
/
Estudios de Seguimiento
/
Cisplatino
/
Quimioterapia
/
Extremidades
/
Hipertermia Inducida
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2012
Tipo del documento:
Artículo
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