Application of the Oxford classification of IgA nephropathy to predict renal outcome / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 102-107, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-284296
ABSTRACT
<p><b>OBJECTIVE</b>To validate the value of the Oxford classification of IgA nephropathy in predicting the renal outcome in Chinese population.</p><p><b>METHODS</b>Retrospective study was done in patients with IgA nephropathy. All slides were re-assessed according to the Oxford classification of IgA nephropathy. The primary end point is doubling serum creatinine, or a 50% reduction in estimated glomerular filtration rate (eGFR), or end-stage renal disease. Pathologic predictors for the progression to the end point were determined by univariate and multivariate Cox regression.</p><p><b>RESULTS</b>Totally 533 patients were enrolled in the study. During the follow-up (median 39 months; range 12-263 months), 5.07% of the patients reached the end point. While tubular atrophy and interstitial fibrosis and arterial/ arteriolar lesion were associated with the endpoint in univariate analysis, only the T score was predictive of the renal outcome in multivariate Cox regression. Combination of the patho- logic lesions had no impact on renal outcome.</p><p><b>CONCLUSION</b>According to the Oxford classification of IgA nephropathy, the degree of tubulointerstitial fibrosis is the only feature independently predictive of renal outcome.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Clasificación
/
Glomerulonefritis por IGA
/
Riñón
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2013
Tipo del documento:
Artículo
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