Advances in research on G protein-coupled inward rectifier K(+) channel gene / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 426-430, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-284355
ABSTRACT
G protein-coupled inward rectifier K(+) channel 4(GIRK4) is a G protein-coupled inward rectifier potassium channel family member. Encoded by the KCNJ5, it is widely distributed in the mammalian heart, brain, and other tissues and organs. Recent studies have demonstrated that the abnormal expression of GIRK4 gene is associated with atrial fibrillation, and meanwhile may be closely related to obesity, metabolic syndrome, and many other clinical conditions. Further research on the role the GIRK4 gene in the pathophysiology of these clinical conditions will definitely facilitate their clinical diagnosis and treatment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fibrilación Atrial
/
Síndrome Metabólico
/
Canales de Potasio Rectificados Internamente Asociados a la Proteína G
/
Genética
Límite:
Humanos
Idioma:
Inglés
Revista:
Acta Academiae Medicinae Sinicae
Año:
2012
Tipo del documento:
Artículo
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