Clinical characteristics of hereditary and sporadic medullary thyroid carcinoma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 401-404, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-284361
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical characteristics and outcomes of the hereditary medullary thyroid carcinoma (HMTC) and the sporadic medullary thyroid carcinoma (SMTC).</p><p><b>METHODS</b>The clinical data of 78 patients with medullary thyroid carcinoma who underwent surgery in our hospital between July 1980 and May 2011 were retrospectively analyzed.</p><p><b>RESULTS</b>Of these 78 patients, there were 23 HMTC cases and 55 SMTC cases. The HMTC group was significantly younger age of onset [(36.4±13.5) years vs. (46.6±11.2) years, P<0.01] and a lower pre/post-operative serum calcitonin levels [(850.4±110.20) ng/L vs. (1450.4±118.3) ng/L, P<0.01 and (410.8±133.2) ng/L vs. (1585.4±129.5) ng/L, P<0.01] than the SMTC group. In addition, the mean tumor diameter was also significantly smaller in the HMTC group (14.3 mm vs. 21.0 mm in SMTC group, P<0.05). Tumor multifocality was seen in a significantly higher proportion of HMTC cases compared with the SMTC cases (56.6% vs. 29.1%, P<0.05). The overall 10-year survival was 100% in HMTC group and 80.2% in SMTC group (P<0.05).</p><p><b>CONCLUSION</b>HMTC has a better prognosis than SMTC.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Neoplasias de la Tiroides
/
Tasa de Supervivencia
/
Estudios Retrospectivos
/
Clasificación
/
Carcinoma Neuroendocrino
/
Carcinoma Medular
/
Edad de Inicio
/
Genética
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Acta Academiae Medicinae Sinicae
Año:
2012
Tipo del documento:
Artículo
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