Correlations of podocyte injury with glucose regulated protein 78 expression and proteinuria in patients with diabetic nephropathy / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 359-363, 2012.
Article
en En
| WPRIM
| ID: wpr-284369
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ABSTRACT
<p><b>OBJECTIVE</b>To explore the podocyte injury in patients with diabetic nephropathy (DN) and analyze its relationship with glucose regulated protein 78 (GRP78) and proteinuria.</p><p><b>METHODS</b>The clinical data of 48 patients diagnosed as DN by renal biopsy were reviewed. All patients were divided into two groups according to proteinuria (>3.5 g/d, n=31 and 3.5 g/d, n=17). The density of podocytes was illustrated by immunohistochemistry staining of Wilms tumor-1 (WT-1), and the immunofluorescence double-staining results of synaptopodin and GRP78 in podocytes were detected.</p><p><b>RESULTS</b>The podocyte dentistry of urine protein > 3.5 g/d group was significantly lower than that of urine protein>3.5 g/d group urine protein<3.5 g/d group(P=0.003), and it was negatively correlated with proteinuria (P=0.005). The expressions of synaptopodin and GRP78 in podocytes were also negatively correlated with proteinuria (P=0.004 and P=0.001).</p><p><b>CONCLUSION</b>The podocyte injury is aggravated with increased proteinuria in DN patients, along with the decrease of the adaptive ability of endoplasmic reticulum to stress.</p>
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Asunto principal:
Patología
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Proteinuria
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Nefropatías Diabéticas
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Podocitos
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Proteínas de Choque Térmico
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Metabolismo
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Acta Academiae Medicinae Sinicae
Año:
2012
Tipo del documento:
Article