Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 822-824, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-284381
ABSTRACT
<p><b>OBJECTIVE</b>To study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).</p><p><b>METHOD</b>Adopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.</p><p><b>RESULT</b>Intraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.</p><p><b>CONCLUSION</b>The result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dolor
/
Farmacología
/
Quinolizinas
/
Carbenoxolona
/
Química
/
Usos Terapéuticos
/
Relación Dosis-Respuesta a Droga
/
Quimioterapia
/
Alcaloides
/
Analgésicos
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2008
Tipo del documento:
Artículo
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