Inhibitory effects of sinapine on activity of acetylcholinesterase in cerebral homogenate and blood serum of rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 813-815, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-284384
ABSTRACT
<p><b>OBJECTIVE</b>The present study investigated the inhibitory effects of Chinese herb component sinapine on activity of acetylcholinesterase (AChE) in cerebral homogenate and blood serum of rats.</p><p><b>METHOD</b>AChE was prepared from cerebral homogenate and blood serum of rats, respectively. Acetylcholinesterase activity assay kit and Chromatometry were used to detect the AChE activity.</p><p><b>RESULT</b>Sinapine significantly inhibited AChE activity in vitro, with more effective on cerebral homogenate (IC50 3.66 micromol x L(-1)) than blood serum (IC50 22.1 micromol x L(-1)).</p><p><b>CONCLUSION</b>Sinapine could significantly inhibit the cerebral AChE activity and may be a promising drug used for prevention and cure of Alzheimer's disease as a cholinesterase inhibitor.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Acetilcolinesterasa
/
Sangre
/
Encéfalo
/
Colina
/
Inhibidores de la Colinesterasa
/
Biología Celular
/
Usos Terapéuticos
/
Quimioterapia
/
Enfermedad de Alzheimer
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS