Influence of borneol on nasal absorption of Ligustrazinee / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 259-261, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-284424
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the influence of borneol on nasal absorption enhancement of ligustrazine.</p><p><b>METHOD</b>The rats were randomly divided into 3 groups Xiongbing nasal spray group (group A), Chuanxiong nasal spray group (group B) and Xiongbing group by decoction intragastric administration (group C). All the rats were decapitated at several time points after administration. The whole brains of rats were taken to homogenate and detected the concentrations of ligustrazine.</p><p><b>RESULT</b>Compared with group B and C, group A has its characteristics quick absorption, quick distribution and quick excretion of ligustrazine.</p><p><b>CONCLUSION</b>Nasal administration is a quick-acting way for ischemic cerebral vessel insufficientia. Borneol promoted nasal absorption of ligustrazine into brain.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Pirazinas
/
Transporte Biológico
/
Canfanos
/
Farmacocinética
/
Cinética
/
Vías de Administración de Medicamentos
/
Nariz
/
Ratas Sprague-Dawley
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2008
Tipo del documento:
Artículo
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