Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 101-103, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-285022
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the polymorphism of HLA-DRB1 alleles and type 2 diabetes mellitus in Yi nationality of Yunnan.</p><p><b>METHODS</b>Polymerase chain reaction-sequence specific primers (PCR-SSP) genotyping method was conducted in 79 patients with type 2 diabetes mellitus and 47 ethnically matched controls in Yi Nationality Autonomous Prefecture, Chuxiong.</p><p><b>RESULTS</b>HLA-DR7 and DR11 allele frequencies in type 2 diabetic mellitus patients were significantly higher than those in non-diabetic control subjects respectively(P is 0.009, RR is 8.329;P is 0.029, RR is 7.734).</p><p><b>CONCLUSION</b>DR7 and DR11 alleles are probably susceptible genes of type 2 diabetes mellitus in Yunnan Yi nationality.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Datos de Secuencia Molecular
/
Secuencia de Bases
/
Antígenos HLA-DR
/
China
/
Análisis de Secuencia de ADN
/
Predisposición Genética a la Enfermedad
/
Diabetes Mellitus Tipo 2
/
Alelos
/
Cadenas HLA-DRB1
/
Frecuencia de los Genes
Límite:
Adulto
/
Anciano
/
Aged80
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2007
Tipo del documento:
Artículo
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