Study on the association of polymorphisms in homocysteine metabolism related enzymes with deep venous thrombosis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 635-639, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-285062
ABSTRACT
<p><b>OBJECTIVE</b>To explore the significance of gene mutation of methylenetetrahydrofolate reductase (MTHFR) C677T, methionine synthase (MS) 2756 AG and cystathionine beta-synthase (CBS) 844ins68 in the development of deep venous thrombosis.</p><p><b>METHODS</b>One hundred and three cases of deep venous thrombosis (DVT group) and 250 healthy subjects (control group) were recruited in the study. The polymorphisms of MTHFR C677T, MS A2756G and CBS 844ins68 were detected by PCR-restriction fragment length polymorphism(PCR-RFLP).</p><p><b>RESULTS</b>The prevalences of TT genotypes of MTHFR (C677T) between DVT group and normal control group had significant difference (27.2% vs 17.2%, P< 0.05), the prevalence of AG genotypes of MS A2756G in the DVT group was less than that in the control group (9.7% vs 19.2%, P< 0.05). The prevalence of 677T-2756A haplotype in the DVT group was higher than that in the control group (P< 0.05), the prevalence of 677C-2756A haplotype in the DVT group was less than that in the control group (P< 0.05). There were no significant differences in the prevalences of CBS 844ins68 mutation.</p><p><b>CONCLUSION</b>The homozygote of MTHFR C677T (TT) may be a risk factor of DVT. MS A2756 G(AG) genotypes may reduce the development of DVT. The 677T-2756A haplotype may be a risk factor of DVT. The 677C-2756A haplotype may be a protective factor of DVT. The prevalence of gene mutation of CBS 844ins68 might vary with different ethnic group or geographic regions.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
5-Metiltetrahidrofolato-Homocisteína S-Metiltransferasa
/
Haplotipos
/
Mutación Puntual
/
Trombosis de la Vena
/
Predisposición Genética a la Enfermedad
/
Cistationina betasintasa
/
Metilenotetrahidrofolato Reductasa (NADPH2)
/
Alelos
/
Frecuencia de los Genes
Tipo de estudio:
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2006
Tipo del documento:
Artículo
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