Correlation between the polymorphism of platelet glycoprotein GPIb α Kozak gene and transient ischemic attack / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 561-564, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-285076
ABSTRACT
<p><b>OBJECTIVE</b>Genic susceptibility could increase the risk of transient ischemic attack (TIA). The objective of this study is to investigate the relationship between the polymorphism of platelet glycoprotein GPIb α Kozak gene and TIA in Qindao Han population.</p><p><b>METHODS</b>The polymorphisms of platelet glycoprotein GPIb α Kozak gene -5T/C in TIA patients and normal control were detected with sequence-specific primers polymerase chain reaction (PCR-SSP).</p><p><b>RESULTS</b>The prevalence of the CC genotype and C alleles were significantly higher in TIA patients than in the control group (P<0.05). The positive correlation between C allele and TIA was showed by logistic regression analysis (P=0.016).</p><p><b>CONCLUSION</b>The -5T/C polymorphism of the platelet glycoprotein GPIb α Kozak gene is implicated in the pathogenesis of TIA. C allele is an independent risk factor for TIA.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Secuencia de Bases
/
Ataque Isquémico Transitorio
/
Reacción en Cadena de la Polimerasa
/
Análisis de Secuencia de ADN
/
Complejo GPIb-IX de Glicoproteína Plaquetaria
/
Predisposición Genética a la Enfermedad
/
Alelos
/
Frecuencia de los Genes
/
Genética
Tipo de estudio:
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2006
Tipo del documento:
Artículo
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