Characteristics of IGF-II gene imprinting in twin placentas / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 497-501, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-285092
ABSTRACT
<p><b>OBJECTIVE</b>To compare insulin-like growth factor II (IGF-II) gene imprinting in twin placentas with singleton ones and to determine whether imprinting was influenced by assisted reproductive technology, zygosity and fetal sex.</p><p><b>METHODS</b>One hundred and sixty cases of twin placentas and 42 cases of singleton ones were recruited. Allele-specific IGF-II expression was determined by reverse transcription-PCR combined with analysis of an Apa I-sensitive restriction fragment length polymorphism.</p><p><b>RESULTS</b>Although the incidence of IGF-II imprinting loss was higher in normal twin placentas than in singleton ones (20.6% vs 8.7%), there was no statistical significance. There were no significant differences between twins conceived by assisted reproductive technology and those conceived spontaneously (17.9% vs 24.4%), and between dizygotic and monozygotic twins (22.4% vs 16.7%). The incidence of IGF-II imprinting loss in placenta of female twins was statistically higher than that of male ones (26.4% vs 9.8%).</p><p><b>CONCLUSION</b>The risk of IGF-II gene imprinting loss is higher in female twins and has no relationship with assisted reproductive technology and zygosity.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Placenta
/
Polimorfismo Genético
/
Gemelos
/
Factor II del Crecimiento Similar a la Insulina
/
Edad Materna
/
Impresión Genómica
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Genética
/
Metabolismo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
/
Recién Nacido
/
Embarazo
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2006
Tipo del documento:
Artículo
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