Risk factors and time-trends of cytomegalovirus (CMV), syphilis, toxoplasmosis and viral hepatitis infection and seroprevalence in human immunodeficiency virus (HIV) infected patients
Annals of the Academy of Medicine, Singapore
;
: 667-673, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-285576
ABSTRACT
<p><b>INTRODUCTION</b>Chronic bacterial, viral and parasitic infections contribute to the morbidity and mortality associated with human immunodeficiency virus (HIV) infection. This study investigated risk factors and time-trends of the seroprevalence of cytomegalovirus (CMV), toxoplasmosis and hepatitis A total antibody; and co-infection with syphilis, hepatitis B and hepatitis C among newly diagnosed HIV individuals in Singapore.</p><p><b>MATERIALS AND METHODS</b>This was a cross-sectional study. A random sample of 50% of HIV infected patients who visited the Communicable Disease Centre (CDC), Singapore for first-time care from January 2006 to December 2011 were analysed.</p><p><b>RESULTS</b>Among the 793 study subjects, 93.4% were male; 77.9% of them were of Chinese ethnicity; mean age at HIV diagnosis was 41.4 years; and the mean baseline CD4+ T-cell count was 222 cells/mm³. The prevalence of sero-reactivity for CMV was 96.8%; hepatitis A 40.9%; and toxoplasmosis 23.7%. Co-infection with syphilis was identified in 12.3%; hepatitis B 8.1%; and hepatitis C 2%. Among those co-infected with hepatitis C, 73.3% of them were intravenous drug user (IVDU). Syphilis co-infection was significantly more common among men who have sex with men (MSM) (multivariate OR 2.53, 95% CI, 1.31 to 4.90, P = 0.006).</p><p><b>CONCLUSION</b>This study described the baseline rates of HIV co-infection with syphilis, hepatitis B and C in Singapore, and sero-reactivity to CMV, toxoplasmosis and hepatitis A. The increased rates compared to the general population may have important consequences for disease progression, response to antiretroviral treatment and long-term general health.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Singapur
/
Factores de Tiempo
/
Sangre
/
Sífilis
/
Infecciones por VIH
/
Oportunidad Relativa
/
Estudios Seroepidemiológicos
/
Toxoplasmosis
/
Epidemiología
/
Estudios Transversales
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Annals of the Academy of Medicine, Singapore
Año:
2013
Tipo del documento:
Artículo
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