Your browser doesn't support javascript.
loading
Clinical Analysis of Drug-induced Liver Injury Caused by Polygonum multiflorum and its Preparations / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 1442-1447, 2015.
Artículo en Chino | WPRIM | ID: wpr-286364
ABSTRACT
<p><b>OBJECTIVE</b>To analyze hepatotoxicity of Polygonum multiflorum and clinical character- istics of drug-induced liver injury (DILI) caused by Polygonum multiflorum and its preparations.</p><p><b>METHODS</b>A retrospective study was performed in 158 patients treated at 302 Military Hospital between January 2009 and January 2014. All of them had used Polygonum multiflorum and its preparations before the onset of DILI, and their clinical characteristics and prognoses were analyzed.</p><p><b>RESULTS</b>Of the 158 DILI patients who used Polygonum multiflorum or its preparations, 92 (58.2%) combined with Western medicine or Chinese herbal preparations without Polygonum multiflorum; 66 patients (41.8%) used Polygonum mult florum and its preparations alone. In 66 DILI patients induced by Polygonum multiflorum or its preparations alone, 51 cases (77.3%) were induced by Polygonum multiflorum compounds and 22.7% by single Po- lygonum multiflorum; 4 cases (6.1%) were caused by crude Polygonum multiflorum and 62 (93.9%) by processed Polygonum multiflorum and its preparations. Clinical injury patterns were hepatocellular 92.4% (61 cases), cholestatic 1.5% (1 case), and mixed 6.1% (4 cases). Pathological examination was per- formed by liver biopsy in 32 cases (48.15%), manifested as hepatocellular degeneration and necrosis, fibroplasia, Kupffer cells with pigment granule, and a large number of eosinophil infiltration, were ob- served. Four patients were developed into liver failure, 4 into cirrhosis, and 1 died.</p><p><b>CONCLUSION</b>Polygo- num multiflorum and its preparations could induce DILI, but clinical diagnosis of Polygonum multiflorum induced hepatotoxicity should be cautious.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Medicamentos Herbarios Chinos / Colestasis / Estudios Retrospectivos / Fallo Hepático / Polygonum / Preparaciones de Plantas / Pueblo Asiatico / Diagnóstico / Enfermedad Hepática Inducida por Sustancias y Drogas / Fallopia multiflora Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Integrated Traditional and Western Medicine Año: 2015 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Medicamentos Herbarios Chinos / Colestasis / Estudios Retrospectivos / Fallo Hepático / Polygonum / Preparaciones de Plantas / Pueblo Asiatico / Diagnóstico / Enfermedad Hepática Inducida por Sustancias y Drogas / Fallopia multiflora Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Integrated Traditional and Western Medicine Año: 2015 Tipo del documento: Artículo