Microfluidic cell culture array chip for drug screening assays / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 779-785, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-286642
ABSTRACT
We developed a novel microfluidic cell chip, which enabled drug delivery, fluid control and cell co-culture. The device consisted of an array of 6x6 cell culture chambers, a drug gradient generator and fluidic control valves. Micro-dam structures of the chambers were able to trap cells while loading and drug gradient network generated drug gradient of 6 different concentrations. Also we applied hydraulic valves to control the microfluid and simulate the microenvironment of cells. We had investigated the viability of co-culturing cells in the chip and the ability for drug screening. This microfluidic cell chip has the potential in cell-based research of high throughput drug screening.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Venas Umbilicales
/
Técnicas Biosensibles
/
Células Cultivadas
/
Hepatocitos
/
Biología Celular
/
Células Endoteliales
/
Microfluídica
/
Técnicas Analíticas Microfluídicas
/
Evaluación Preclínica de Medicamentos
/
Métodos
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2009
Tipo del documento:
Artículo
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