Association of surfactant protein D gene polymorphisms at rs3088308 and rs721917 with susceptibility to silicosis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1004-1007, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-286858
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between polymorphisms of surfactant protein D (rs3088308 and rs721917) and the susceptibility to silicosis.</p><p><b>METHODS</b>This case-control study included 125 silicosis patients and 125 individuals exposed to industrial dust but without silicosis (control group), who were strictly matched with the case group for age, gender, work type and cumulative length of dust exposure. The rs3088308 and rs721917 polymorphisms of surfactant protein-D were detected in all the participants using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).</p><p><b>RESULTS</b>The frequencies of T/T, T/A and A/A genotypes of surfactant protein-D rs3088308 locus were 22.2%, 71.2% and 5.6% in the case group, significantly different from the frequencies of 17.6%, 58.4% and 24.0% in the control group, respectively (P<0.05). The frequencies of C/C, C/T and T/T genotypes of rs721917 locus were 17.6%, 56.8% and 25.6% in the case group, similar to the frequencies of 15.2%, 60.0% and 24.8% in the control group, respectively (P>0.05).</p><p><b>CONCLUSION</b>Surfactant protein-D rs3088308 polymorphism is significantly associated with silicosis, and the T allele may be a risk factor for silicosis in individuals exposed to industrial dust.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Silicosis
/
Polimorfismo de Longitud del Fragmento de Restricción
/
Estudios de Casos y Controles
/
Reacción en Cadena de la Polimerasa
/
Factores de Riesgo
/
Predisposición Genética a la Enfermedad
/
Proteína D Asociada a Surfactante Pulmonar
/
Alelos
/
Frecuencia de los Genes
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2016
Tipo del documento:
Artículo
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