Comparisons of efficacy and safety of tolterodine and oxybutynin in children with idiopathic overactive bladder / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 26-28, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-286914
ABSTRACT
<p><b>OBJECTIVE</b>To compare the efficacy and safety of tolterodine and oxybutynin in the treatment of idiopathic overactive bladder in children.</p><p><b>METHODS</b>A total of 204 children with idiopathic overactive bladder were randomly divided into three groups (n=68 each) placebo, tolterodine-treated and oxybutynin-treated. The efficacy and safety were evaluated two weeks after treatment.</p><p><b>RESULTS</b>The effective rate was 25% in the placebo group, 89% in the tolterodine-treated group, and 92% in the oxybutynin-treated group. The effective rate in the two treatment groups was significantly higher than that in the placebo group (P<0.05). There was a similar efficacy between the two treatment groups. The incidence of adverse events in the tolterodine-treated group (28%) was significantly lower than that in the oxybutnin-treated group (57%) (P<0.05).</p><p><b>CONCLUSIONS</b>Tolterodine has a similar efficacy to oxybutynin in the treatment of idiopathic overactive bladder in children, with better safety in pharmacotherapy.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenilpropanolamina
/
Compuestos de Bencidrilo
/
Antagonistas Muscarínicos
/
Cresoles
/
Usos Terapéuticos
/
Quimioterapia
/
Vejiga Urinaria Hiperactiva
/
Tartrato de Tolterodina
/
Ácidos Mandélicos
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adolescente
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2011
Tipo del documento:
Artículo
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