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Development of selective androgen receptor modulators and their therapeutic applications / 中华男科学杂志
National Journal of Andrology ; (12): 162-168, 2002.
Artículo en Inglés | WPRIM | ID: wpr-287257
ABSTRACT
Androgens control a broad range of physiological functions. The androgen receptor (AR), a steroid receptor that mediates the diverse biological actions of androgens, is a ligand inducible transcription factor. Abnormalities in the androgen signaling system result in many disturbances ranging from changes in gender determination and sexual development to psychiatric and emotional disorders. Androgen replacement therapy can improve many clinical conditions including hypogonadism and osteoporosis, but is limited by the lack of efficacious and safe therapeutic agents with easy delivery options. Recent progress in the area of gene regulation by steroid receptors and by selective receptor modulators provides an opportunity to examine if selective androgen receptor modulators (SARMs) could address some of the problems associated with current androgen therapy. Since the composition of the transcriptional initiation complex recruited by liganded AR determines the specificity of gene regulation, synthetic ligands aimed at initiating transcription of tissue and promoter specific genes offers hope for developing better androgen therapy. Establishment of assays that predict synthetic ligand activity is critical for SARM development. Advancement in high throughput compound screening and gene fingerprinting technologies, such as microarrays and proteomics, will facilitate and accelerate identification of effective SARMs.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / Receptores Androgénicos / Química / Acetato de Clormadinona / Receptores Citoplasmáticos y Nucleares / Congéneres de la Testosterona / Antagonistas de Receptores Androgénicos / Antagonistas de Andrógenos / Andrógenos Tipo de estudio: Estudio pronóstico Límite: Humanos / Masculino Idioma: Inglés Revista: National Journal of Andrology Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / Receptores Androgénicos / Química / Acetato de Clormadinona / Receptores Citoplasmáticos y Nucleares / Congéneres de la Testosterona / Antagonistas de Receptores Androgénicos / Antagonistas de Andrógenos / Andrógenos Tipo de estudio: Estudio pronóstico Límite: Humanos / Masculino Idioma: Inglés Revista: National Journal of Andrology Año: 2002 Tipo del documento: Artículo