Role of arsenolite on 8-isoprostane of asthmatic mice plasm / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1758-1760, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-287306
ABSTRACT
<p><b>OBJECTIVE</b>Through the establishment of mouse' ovalbumin- sensitized asthmatic model and the observation of the 8-Isoprostane of plasm, to evaluate the therapeutic effects of arsenolite on asthmatic mice.</p><p><b>METHOD</b>Forty-two healthy Kunming male mice were randomly divided into control group and experience groups, the latter were treated with dexamethasone, arsenolite. Lung function were tested, 8-isoprostane of plasm and WBC of BALF were measured.</p><p><b>RESULT</b>Lung function improved after treating with dexamethasone or arsenolite. The WBC of asthmatic mice were significantly higher than those in control group, and decreased after treating with dexamethasone or arsenolite; 8-Isoprostane of plasm in asthmatic mice was higher than that of control group, and decreased after treating with dexamethasone or arsenolite.</p><p><b>CONCLUSION</b>There is oxidant stress status in asthmatic mice. Arsenolite could lighten airway obstruction, reduce airway high response and redress oxidant stress status in asthmatic mice.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Óxidos
/
Farmacología
/
Arsenicales
/
Pruebas de Función Respiratoria
/
Asma
/
Sangre
/
Líquido del Lavado Bronquioalveolar
/
Materia Medica
/
Dinoprost
/
Distribución Aleatoria
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS